The maps $B{\rm Sp}(1)\rightarrow B{\rm Sp}(n)$
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چکیده
منابع مشابه
Induction of functional Brm protein from Brm knockout mice
Once the knockout of the Brm gene was found to be nontumorigenic in mice, the study of BRM's involvement in cancer seemed less important compared with that of its homolog, Brg1. This has likely contributed to the disparity that has been observed in the publication ratio between BRG1 and BRM. We show that a previously published Brm knockout mouse is an incomplete knockout whereby a truncated iso...
متن کاملRole for Brm in cell growth control.
Recently, we have shown implication of Brm, the catalytic subunit of the SWI/SNF chromatin remodeling complex, in repression of cyclin A expression in quiescent cells. Here, we have examined the fate of cells lacking Brm throughout the cycle. We find that despite elevated levels of cyclins A and E, these cells can respond to serum starvation, however, without reaching a canonical G(0) phase as ...
متن کاملBRG1 and BRM loss selectively impacts RB and P53, respectively: BRG1 and BRM have differential functions in vivo
The SWI/SNF complex is an important regulator of gene expression that functions by interacting with a diverse array of cellular proteins. The catalytic subunits of SWI/SNF, BRG1 and BRM, are frequently lost alone or concomitantly in a range of different cancer types. This loss abrogates SWI/SNF complex function as well as the functions of proteins that are required for SWI/SNF function, such as...
متن کاملAssociation of BRM promoter polymorphisms and esophageal adenocarcinoma outcome
PURPOSE Brahma (BRM) is a critical catalytic subunit of the SWI/SNF chromatin remodeling complex; expression of BRM is commonly lost in various cancer types. BRM promoter polymorphisms (BRM-741; BRM-1321) are associated with loss of BRM expression, and with cancer risk/survival. We evaluated these two polymorphisms in the overall survival (OS) of esophageal adenocarcinoma (EAC) patients. RESU...
متن کاملThe silencing of the SWI/SNF subunit and anticancer gene BRM in Rhabdoid tumors
Rhabdoid sarcomas are highly malignant tumors that usually occur in young children. A key to the genesis of this tumor is the mutational loss of the BAF47 gene as well as the widespread epigenetic suppression of other key anticancer genes. The BRM gene is one such epigenetically silenced gene in Rhabdoid tumors. This gene codes for an ATPase catalytic subunit that shifts histones and opens the ...
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ژورنال
عنوان ژورنال: Proceedings of the American Mathematical Society
سال: 1975
ISSN: 0002-9939
DOI: 10.1090/s0002-9939-1975-0380794-x